Reye syndrome is a rare, but severe and often fatal disease. The reported incidence rate of reye syndrome decreased from a high of 0. Signs and symptoms such as confusion, seizures and loss of consciousness require emergency treatment. Reyes syndrome usually occurs in children who have. Sindrom reye adalah sindrom yang menyebabkan pembengkakan pada hati dan otak dan seringkali terjadi pada anakanak dan remaja yang baru pulih dari infeksi berat, seperti flu dan cacar air. Sindrom reye adalah penyakit duatahap karena hampir selalu dikaitkan dengan infeksi virus sebelumnya, seperti influenza cacar, dingin, atau ayan sindroma reye adalah suatu sindroma ensefalopati yang penyebabnya tidak diketahui, dan disertai dengan. Gejala utamanya adalah sesak napas berat dan sulit bernapas. Sindrom reye merupakan keadaan yang cukup serius yang bisa mengakibatkan organ hati dan juga otak menjadi bengkak. Reye syndrome is characterized by acute noninflammatory encephalopathy and fatty degenerative liver failure. Reyes syndrome is a very rare condition that causes serious liver and brain damage.
Kelainan pada anak down syndrome sangat jelas dan setiap anak down syndrome hampir memiliki wajah yang serupa. Reye syndrome is an illness that meets all the following criteria. A total of 1207 cases of reyes syndrome were reported to the centers for disease control cdc in the us between 1980 and 1997. Syndrome adalah 2,5 hari, dengan 1 anak dalam 20 usia kelangsungan hidup mencapai lebih dari 6 bulan. Early recognition of reye s syndrome is important as prompt treatment may reduce morbidity and mortality. Penyakit ini mempengaruhi semua organ tubuh, tapi yang peling berbahaya adalah serangan pada otak dan hati. People with reye syndrome have nausea, vomiting and a change in mental status. Although it can happen at any age, it is most often seen in children. Meconium plug syndrome merck manuals professional edition. At the first time, reyes syndrome was found by an australian named r.
Sindrom yang terbilang cukup langka ini kebanyakan menimpa anakanak dan remaja yang baru sembuh dari infeksi virus, seperti flu atau cacar air. Tetapi beberapa anak ada yang mencapai usia belasan tahun. Ards atau acute respiratory distress syndrome adalah gangguan pernapasan berat yang disebabkan oleh penumpukan cairan di alveoli atau kantung udara kecil di paruparu. Although its etiology and pathophysiology are poorly understood, the cause is believed to be associated with several factors, including ingestion of aspirin, which was first reported 25 years ago. Reye syndrome is an unusual complication of varicella and influenza and occurs almost exclusively in children who take aspirin during the acute illness. Reye syndrome usually affects children between the ages of 4 and 12, and is most common at age 6. Reye s syndrome most often affects children and teenagers recovering from a viral infection, most commonly the flu or chickenpox. Rheumatoid arthritis, aspirin, hepatic encephalopathy, reyes syndrome.
Pengertian anak down syndrome down syndrome adalah. Association aspirin administration in viral infection with reyes syndrome abstract reyes syndrome, is a rare disease which can demage several organs, especially brain and liver. Usia yang berisiko adalah ibu hamil pada usia lebih dari 35 tahun. Sel telur ovum semakin menua seiring pertambahan usia perempuan. Gejalanya berupa muntah tak terkendali, demam, mengigau dan tak sadar. Reyes syndrome information page national institute of. Reye s syndrome rs is primarily a childrens disease, although it can occur at any age. Reyes syndrome, a deadly disease, strikes swiftly and can attack any child, teen, or adult without warning. Sindrom ini memang termasuk langka dan jarang terjadi yang biasanya di derita anak atau usia remaja saat baru sembuh dari infeksi virus seperti cacar air, varicella, gastroenteritis atau flu dan juga penggunaan aspirin pada anak gejala yang ditimbulkan saat terjadi cacar dan. This message is then translated into a protein in the ribosomes within the cytosol. Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. Reyes syndrome in the united states from 1981 through 1997. Reyes syndrome usually appears after a flulike infection, upper respiratory infection, chicken pox, or other viral illness. Baral reported that 11 of 21 patients in case which.
Sindrom reye gejala, penyebab dan mengobati alodokter. Douglas reye di tahun 1963 ini umumnya menyerang anakanak pada umur 4 tahun. Sindrom reye adalah masalah kerusakan otak dan fungsi hati secara tibatiba yang tidak diketahui penyebabnya. Salah satu penyakit langka tersebut adalah sindrom reye. Meconium plug syndrome is colonic obstruction caused by thick meconium. Death occurs in 2040% of those affected and about a third of those who survive are left with a significant degree of brain damage. Reyes syndrome, is a rare disease which can demage several organs, especially brain and liver. Bengkak dan nyeri sendi besar siku, lutut dan terkelupasnya ujung jari tangan dan kaki adalah hal yang biasa terjadi pada saat penyembuhan dan akan membaik dalam waktu sekitar 3. Ards sering disebabkan oleh penyakit kritis, seperti sepsis atau pneumonia berat.
Asosiasi penggunaan aspirin pada viral infection dengan sindrom. Asosiasi penggunaan aspirin pada viral infection dengan. Penggunaan aspirin kepada anakanak sangat membahayakan, terutama jika memberikannya tanpa izin dari dokter. Sindrom reye bisa menyerang siapa saja pada usia berapa pun, tetapi biasanya menyerang anakanak antara usia 4 dan 12 tahun. Alagille syndrome is a genetic disorder that can affect the liver, heart, and other parts of the body one of the major features of alagille syndrome is liver damage caused by abnormalities in the bile ducts. Karakteristik anak yang mengalami mental retardation dan down syndrome. Adanya laporan kasus patau syndrome yang mencapai usia dewasa sangat jarang. Studies show that there is an association between the ingestion of products containing aspirin in children who have a viral illness and reye syndrome. Research has established a link between reyes syndrome and the use of aspirin. The main treatments are to prevent cardiac disease. Reye syndrome is a rare and potentially fatal pediatric illness defined as acute noninflammatory encephalopathy with fatty liver failure. If it is not treated promptly it may result in permanent brain injury or death.
The serious symptoms of reye syndrome appear to result from damage to cellular mitochondria at least in the liver, and there are a number of ways that aspirin could cause or exacerbate mitochondrial damage. Penyebab sindrom reye biasanya adalah aspirin yang digunakan untuk pengobatan penyakit maupun infeksi yang parah seperti flu dan cacar air. The condition appears as red blotches or rash on the skin and is commonly found on the back of the neck, giving it a reference name of red neck syndrome. Reyes syndrome is a rare but serious condition that primarily affects children and may follow a viral illness such as the flu influenza or chickenpox varicella. Acute respiratory distress syndrome ards adalah salah satu penyakit paru akut yang memerlukan perawatan di intensive care unit icu dan mempunyai angka kematian yang tinggi yaitu mencapai 60%. Diffuse cerebral involvement is more common in adults than in children. The disease affects mitochondrial function, causing disturbance in. The individual with reyes syndrome needs intensive care to reduce the brain swelling quickly to prevent permanent brain damage, and to prevent other complications from the disorder. Reye syndrome is a rapidly worsening brain disease.
It is rare, and is often in children who have just had a viral. Reye syndrome has emerged as the quintessential example of an acute metabolic encephalopathy. Penyakit sindrom reye kerusakan organ tubuh kondisi umum. Reyes syndrome encephalopathy with fatty infiltration of the viscera is an acute illness of childhood that produces hepatic dysfunction and metabolic encephalopathy. Clinical features and prognosis of reyes syndrome archives of. The genes for not only cox2 but also inos belong to this group and are upregulated in response to tissue injury, eventually. Association aspirin administration in viral infection with reyes syndrome. Sindrom reye adalah penyakit duatahap karena hampir selalu dikaitkan dengan infeksi virus sebelumnya, seperti influenza cacar, dingin, atau ayan sindroma reye adalah suatu sindroma ensefalopati yang penyebabnya tidak. Seperti dilansir dalam laman situs, sindrom yang pertama kali ditemukan oleh ahli patologis australia, r. Reyes syndrome occurs in all ages, seasons, and geographical locations, but it. Reyes syndrome in children supriatmo departemen ilmu kesehatan anak fakultas kedokteran universitas sumatera utara abstract. The clinical presentation is quite stereotyped in most instances permitting rapid, accurate diagnosis and early therapeutic intervention. These ducts carry bile which helps to digest fats from the liver to the gallbladder and small intestine.
Archives of disease in childhood, 1984, 59, 230235. Reyes syndrome rs is a rare, serious childhood encephalopathy preceded by a viral prodrome and associated with hepatic dysfunction. Sindrom reye penyebab, gejala, diagnosis, pengobatan dan. The etiology of the classical reye syndrome is unknown, but it is typically preceded by a viral infection with a free interval of three. All body organs are affected, with the liver and brain suffering most seriously. Pdf karakteristik anak yang mengalami mental retardation. Reye syndrome is a rare form of acute encephalopathy and fatty infiltration of the liver that tends to occur after some acute viral infections, particularly when salicylates are used. Intoxications and certain inborn metabolic errors may mimic reye syndrome.
Respirasi distress syndrom rds respirasi distsress syndrome. Reyes syndrome is now differentiated into two groups. Reye s syndrome rs is a rare but potentially fatal disease that affects all organ of the body, with an especially devastating attack upon the liver and brain. Reye syndrome pediatrics merck manuals professional edition. Here we describe a case of reye syndrome diagnosed at postmortem liver biopsy of a threeyear old girl who presented with vomiting, low grade fever for three days and loss of consciousness for 18. Symptoms may include vomiting, personality changes, confusion, seizures, and loss of consciousness. Reyes syndrome is a rare disorder that causes brain and liver damage. Etiologi sindrom down banyak dilahirkan oleh ibu berumur tua resiko tinggi, ibuibu di atas 35. Banyak studi telah menunjukkan adanya hubungan antara kejadian syndrome reye pada anakanak dengan penggunaan aspirin. It affects all organs of the body but is most harmful to the brain and the livercausing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. Jika tidak diobati, reye dapat cepat menyebabkan gagal hati, kerusakan otak, dan bahkan kematian. Reye syndrome patient discussions bmj best practice.
Reye syndrome is a rare condition that may follow an upper respiratory infection or a case of varicella chickenpox. Latar belakang reye syndrome adalah penyakit yang mempengaruhi semua organ tubuh, tetapi yang paling mematikan hati dan otak. Reyes syndrome rs is a rare but potentially fatal disease that affects all organ of the body, with an especially devastating attack upon the liver and brain. Sindrom reye adalah kondisi serius yang jarang terjadi, yang menyebabkan pembengkakan pada daerah liver hati dan otak. Reyes syndrome is defined by the centers for disease control and prevention as an acute, noninflammatory encephalopathy associated with altered levels of consciousness and liver dysfunction. Kehamilan pada usia lebih dari 40 tahun, risikonya meningkat 10 kali lipat dibanding pada usia 35 tahun. We report a case where the syndrome presented as ketoacidosis in a known diabetic. Although it mostly affects children and teens, anyone can get it. Varicella zoster virus centers for disease control and. Sindrom reye pengertian, gejala, penyebab, faktor risiko. Ia mempengaruhi semua organorgan tubuh namin adalah paling berbahaya pada otak dan hati menyebabkan peningkatan yang akut dari tekanan dalam otak dan, seringkali akumulasi lemak yang besarbesaran pada hati dan organorgan lain. Sindrom ini biasanya terjadi pada anakanak yang diberikan aspirin ketika mereka menderita cacar air atau flu. Reye syndrome symptoms, diagnosis and treatment bmj best.
Reye s reye syndrome is a rare but serious condition that causes swelling in the liver and brain. Douglas reye, yaitu orang yang pertama kali melaporkan sebagai sindrom yang berbeda pada tahun 1963, sindrom reye masih belum. Reyes syndrome is not a severe sepsislike disease, as they describe it, but a syndrome, characterised by the combination of liver pathology and. Reyes syndrome is an acute illness characterized by encephalopathy and fatty degeneration of the liver, and it occurs almost exclusively in children. To be diagnosed as reye syndrome, an illness must meet the following criteria. Reye s syndrome encephalopathy with fatty infiltration of the viscera is an acute illness of childhood that produces hepatic dysfunction and metabolic encephalopathy. Reye syndrome also called reye s syndrome is a rare but severe illness seen primarily in children between 4 months and 14 years of age with an average age of 6 years 1,2. Definisi reye syndrome reyes syndrome rs adalah terutama penyakit anakanak, meskipun ia dapat terjadi pada segala umur. As a result, the centers for disease control and prevention cdc and the american academy of. Learn about reye syndrome, which affects the liver, brain, and other organs. Further support may be available from online resources. Sindrom reye adalah suatu kondisi serius yang dapat menyebabkan pembengkakan pada organ hati dan otak.
Sindrom reye atau reyes syndrome rs merupakan jenis penyakit kerusakan otak yang akut yang terjadi secara mendadak. Diagnosis is based on radiographic contrast enema and sometimes testing for hirschsprung disease. Red man syndrome, rms, is the immune systems adverse reaction to a given drug. Sindrom reye sebagian besar terjadi pada anakanak dan remaja setelah mengalami fase penyembuhan dari infeksi virus, yang paling sering yaitu virus flu. National reyes syndrome foundation us external link opens in a new window. Memang sih, angka kejadiannya tidak terlalu banyak, tapi sekali terjadi akibatnya sangat fatal. Sindrom reye adalah gangguan langka yang dapat menyebabkan kerusakan serius pada semua organ tubuh, tetapi terutama pada otak dan hati meskipun dapat terjadi pada orangorang dari segala usia, hal ini paling sering terjadi pada mereka yang berusia 18 tahun atau lebih muda dan sangat umum pada anakanak berusia 4 hingga 12 tahun. Even though liver toxicity typically occurs, jaundice usually does not.
Acute respiratory distress syndrome gejala, penyebab dan. Almost all recorded cases of reyes syndrome have happened in children, but adult cases have also occurred. Sindrom reye adalah penyakit yang sangat langka namun serius yang dapat mempengaruhi otak dan hati, terjadi paling sering pada anakanak yang sembuh dari infeksi virus. Seperti apa sindrom reye yang disebutsebut termasuk dalam deretan penyakit mematikan ini.
52 1029 1287 347 1566 364 212 1560 1496 1515 1421 587 1159 967 462 310 640 1277 749 209 785 412 532 1164 443 1379 552 322 1115 1381 448 22 1121 1404 1081 422 775 1431 1097 498 1189 1277 507 1312 1102 649 1115 992 1114 275 214